Affiliations and Support
— research
Cells offer numerous examples of complex systems that perform specific tasks with remarkable precision and efficiency.
We aim to re-engineer these natural systems using the technique of DNA origami.
Our aim is to construct functional DNA origami nanostructures inspired by natural protein complexes.
Our aim is to use DNA origami to manipulate cellular membranes in vivo.
— inside our toolbox
These are the core techniques driving our research:
— DNA origami
— Single-molecule biophysics
— Transmission electron microscopy
— Fluorescence microscopy
— Cryo-electron microscopy
— Flow-induced dispersion analysis
Dilatable DNA origami nanopores as nuclear pore mimics_
Bertosin, van Herk et al., bioRxiv 2026
How can we study the nuclear pore complex from a simplified, bottom-up approach? In this work we combine DNA origami, single-molecule FRET, and fluorescence lifetime imaging to build dilatable and contractable dynamic nanopores coated with NPC proteins to study molecular transport through lipid membranes.
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Elucidating the nanoscopic organization and dynamics of the NPC_
Baumann et al., Nucleus 2025
We report key recent advancements discussed at the Selective Transport Control in Biological and Biomimetic Nanopores meeting (Monte Verità, Switzerland, 2024) that gathered nuclear pore complex (NPC) experts from a range of disciplines.
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The Team_
